Vacancies and Studentships.

We have a potential studentship working in the IGF2R domain 11 research project that would be aimed at engineering domain 11 for specific ligand binding. Recently we have used NMR, X-ray crystallography and yeast surface display assays to engineer an Insulin growth factor 2 (IGF2) super-antagonist based on domain 11 from the IGF2 receptor (IGF2R) (Crump & Hassan and co-workers 2012, Science 238, 1209-1213.) and the proposed PhD will build on this success by adapting domain 11 to a wider range of ligands. This studentship would be funded by the SWSBIO DTP (BBSRC) and would start for four years in October 2015.  Please contact matt.crump@bristol.ac.uk for further details or see http://www.bristol.ac.uk/swdtp/projects_available/2015_projects_available/2015_wcb_bristol.html. Please note there will be an interview process for these studentships and final selection for a PhD will be based on this performance.

Supervisors: Prof. Matthew Crump (School of Chemistry, University of Bristol), Paul Race (School of Biochemistry, University of Bristol), Bass Hassan (Sir William Dunn School of Medicine, University of Oxford).