Dr Chris WIlliams

 

Chris did his PhD in the group of Dr Stefan Bagby in Bath. He joined Matt’s group in 2004 where he is an expert in protein expression, purification, NMR data acquisition and structure determination. He has been involved in a wide variety of projects in the group.

Publications

2013

Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements
Fuengfuloy, P., Chuawong, P., Suebka, S., Wattana-Amorn, P., Williams, C., Crump, M. P., Songsiriritthigul, C. & Crump, M. P. May 2013 In : Protein Expression and Purification. 89, 1, p. 25-32 8 p.

(1)H, (13)C and (15)N chemical shift assignments of unliganded Bcl-x(L) and its complex with a photoresponsive Bak-derived peptide
Wysoczanski, P., Mart, R. J., Loveridge, E. J., Williams, C., Whittaker, S. B-M., Crump, M. P. & Allemann, R. K. 2013 In : Biomolecular NMR assignments. 7, p. 187-191 10.1007/s12104-012-9378-x

Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate
Loveridge, E. J., Matthews, S. M., Williams, C., Whittaker, S. B-M., Günther, U. L., Evans, R. M., Dawson, W. M., Crump, M. P. & Allemann, R. K. 2013 In : Biomolecular NMR assignments. 7, p. 61-64

2012

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L)
Wysoczanski, P., Mart, R. J., Loveridge, E. J., Williams, C., Whittaker, S. B. -M., Crump, M. P. & Allemann, R. K. 9 May 2012 In : Journal of the American Chemical Society. 134, 18, p. 7644-7647 4 p.

2011

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
Loveridge, E. J., Tey, L-H., Behiry, E. M., Dawson, W. M., Evans, R. M., Whittaker, S. B. -M., Guenther, U. L., Williams, C., Crump, M. P. & Allemann, R. K. 21 Dec 2011 In : Journal of the American Chemical Society. 133, 50, p. 20561-20570 10 p.

Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity
Dall’Aglio, P., Arthur, C., Williams, C., Vasilakis, K., Maple, H. J., Crosby, J., Crump, M. P. & Hadfield, A. T. 28 Jun 2011 In : Biochemistry. 50, 25, p. 5704-5717 14 p.

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins
Brown, C., Campos Leon, K., Strickland, M., Williams, C., Fairweather, V. S. S., Brady, R. L., Crump, M. P. & Gaston, K. Apr 2011 In : Nucleic Acids Research. 39 , 7, p. 2969-2980 12 p.

2010

Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase
Wattana-Amorn, P., Williams, C., Płoskoń, E., Cox, R. J., Simpson, T. J., Crosby, J. & Crump, M. P. Mar 2010 In : Biochemistry. 49, p. 2186 – 2193 8 p.

2009

Structure and malonyl CoA-ACP transacylase binding of Streptomyces coelicolor fatty acid synthase acyl carrier protein
Arthur, C. J., Williams, C., Pottage, K., Płoskoń, E., Findlow, S. C., Burston, S. G., Simpson, T. J., Crump, M. P. & Crosby, J. Aug 2009 In : ACS Chemical Biology. 4 , 8, p. 625 – 636 12 p.

Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3(2)
Evans, S. E., Williams, C., Arthur, C. J., Ploskon, E., Crosby, J., Cox, R. J., Willis, C. L., Simpson, T. J. & Crump, M. P. 2009 In : Journal of Molecular Biology. 389, p. 511 – 528

2008

An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein
Evans, S. E., Williams, C., Arthur, C. J., Burston, S. G., Simpson, T. J., Crosby, J. & Crump, M. P. Oct 2008 In : ChemBioChem. 9, p. 2424 – 2432 9 p.

A Mammalian Type I Fatty Acid Synthase Acyl Carrier Protein Domain Does Not Sequester Acyl Chains
Ploskon, E. A., Arthur, C. J., Evans, S. E., Williams, C., Crosby, J., Simpson, T. J. & Crump, M. P. 2008 In : Journal of Biological Chemistry. 283 (1), p. 518 – 528 11 p.

2007

Structural Insights into the Interaction of Insulin-like Growth Factor 2 with IGF2R Domain 11
Williams, C., Rezgui, D., Prince, S. N., Zaccheo, O. J., Foulstone, E. J., Forbes, B. E., Norton, R. S., Crosby, J., Hassan, A. B. & Crump, M. P. Sep 2007 In : Structure. 15 (9), p. 1065 – 1078 14 p.