Emily Lai

 

Emily attained her Bsc (Hons) in Chemistry from the University of Bristol in 2023. Her final-year project, completed under the supervision of Prof Matthew Crump, involved the successful synthesis of a carefully designed mimic substrate for the putative esterase in the biosynthetic pathway of the antibiotic mupirocin.

Her PhD involves delving deeper into this field looking more closely at the spatiotemporal control governing the interactions between these enzymes and their ligands. By using various NMR assay techniques  which allow for real-time observations of substrate processing, coupled with the use of specific substrate mimetic probes and Cryo-EM to capture intermediate conformations of these proteins, she hopes her project will significantly enhance our understanding of systems offering insights to help tackle the global threat of antibiotic resistance.