(Updated August 2023).


(136) Winter et al. In Preparation

(135) Bowen et al. In Preparation

(134) Winter AJ, Khanizeman N, Barker-Mountford AMC, Devine AJ, Wang L, Davies JA, Race PR, Williams C, Simpson TJ, Willis CL, Crump MP. Structure and Function of the a-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase. Angew. Chemie Int. Ed. E202312514

(133) Cavini IA, Winter AJ, Pereira HM, Woolfson DN, Crump MP, Garratt RC (2023) X-ray structure of the metastable SEPT14-SEPT17 coiled coil reveals a hendecad region crucial for heterodimerisation. Acta Cryst D. Struct. Biol. D79, 881-894

(132) Meade RM, Allen SG, Williams C, Tang S, Crump MP, Mason JM (2023) An N-terminal alpha-synuclein fragment binds lipid vesicles to modulate lipid-induced aggregation. Cell Rep. Phys. Sci. 4, 101563.

(131) Hutchins GH, Noble CEM, Bunzel HA, Williams C, Dubiel P, Yadav SKN, Molinaro PM, Barringer R, Blackburn H, Hardy BJ, Parnell AE, Landau C, Race PR, Oliver TAA, Koder RL, Crump MP, Schaffitzel, Oliviera ASF, Mulholland AJ, Anderson JLR (2023) An expandable, modular de novo protein platform for precision redox engineering. Proc. Natl. Acad. Sci. 120, e2306046120

(130) Vriens E, De Ruysscher D, Weir AMN, Dekimpe S, Steurs G, Shemy A, Persoons L, Santos AR, Williams C, Daelemans D, Crump MP, Voet A, De Borggraeve, Lescrinier E, Masschelein J (2023) Polyketide synthase-mediated O-methyloxime formation in the biosynthesis of the oximidine anticancer agents Angew Chem. Int. Ed. 62, e202304476


(129) Devine AJ, Parnell AE, Back CR, Lees NR, Johns ST, Zulkepli AZ, Barringer R, Zorn K, Stach JEM, Crump MP, Hayes MA, van der Kamp MW, Race PR and Willis CL (2022) The role of cytochrome P450 AbyV in the final stages of abyssomicin C biosynthesis. Angew. Chem. Int. Ed. 62, e202213053

(128) Winter AJ, Rowe MT, Weir ANM, Akter N, Mbatha SZ, Walker PD, Williams C, Song Z, Race PR, Willis CL, Crump MP. (2022) Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. Angew. Chem. Int. Ed. 61, e202212393

(127) Serapian SA, Crosby J, Crump MP van der Kamp, MW (2022) The path to actinorhodin: Atomistic simulations to unravel the causes of regio- and stereoselective octaketide reduction in Streptomyces Cœlicolor. JACS Au. 2, 972-984

(126) Bowen JI, Wang L, Crump MP, Willis CL (2022) Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans. Org. & Biomol. Chem. 20, 1150-1175


(125) Landin EJB, Williams C, Ryan SA, Bochel A, Akter N, Redfield C, Session RB, Dedi N, Taylor RJ, Crump MP (2021). The structural basis for high affinity binding of a1-acid glycoprotein to the potent anti-tumour compound UCN-01. J. Biol. Chem. 297, 101392

(124) Bowen JI, Wang L, Crump MP and Willis CL (2021) Ambruticins: Tetrahydropyran ring formation and total synthesis. Org. Biomol. Chem. 19, 6210-6215

(123) Antón Z, Weijman JF, Williams C, Mantell J, Yip YY, Cross JA, Steiner RA, Crump MP, Woolfson DN, Dodding MP (2021) Molecular mechanism for kinesin-1 direct membrane recognition. Science Adv. 7 (31)

(122) Dawson WM, Lang EJM, Rhys GG, Shelley KL, Williams C, Brady RL, Crump MP, Mulholland AJ, Woolfson DN (2021) Dynamic switching between multiple states of a de novo peptide assembly. Nature Comm. 12, 1530

(121) Thongkawphueak T, Winters A, Williams C, Maple HJ, Soontaranon S, Kaewhan C, Soontaranon S, Campopiano DJ, Crump MP, Wattana-Amorn P (2021) Solution structure and conformational dynamics of a doublet ACP from prodigiosin biosynthesis. Biochemistry, 60, 219-230


(120) Bunnak W, Winter AJ, Lazarus CM, Crump MP, Race PR, Wattana-Amorn P (2021) SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase. FEBS Lett. 595, 133-144

(119) Walker, PD, Weir ANM, Willis CL, Crump MP (2021) Polyketide β-Branching: Diversity, Mechanism and Selectivity. Nat. Prod. Rep. 38, 723-756

(118) Davies JA, Bull FM, Walker PD, Weir ANM, Masschelein J, Lavigne R, Simpson TJ, Race PR, Crump MP, Willis CL (2020) Total Synthesis of Kalimantacin A. Org. Lett. 22, 6349-6353.

(117) Bochel AJ, Williams C, McCoy AJ, Hoope H-J, Winter AJ, Nicholls RD, Harlos K, Jones EY, Berger I, Hassan AB, Crump MP * (2020) Structure of the human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11 uncovers the mannose 6-phosphate binding site of domain 9. Structure 28, 1-13

(116) Curnow P,  Hardy BJ, Dufour V, Arthur CJ, Stenner R, Hodgson LR, Verkade P, Williams C, Shoemark DK, Sessions RB, Crump MP, Jones MR, Anderson RJL (2020) Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein. Sci. Rep. 10, 15203.

(115) Wang L, Song Z, Race PR, Spencer J, Simpson TJ, Crump MP, Willis CL. (2020) Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics. Chem. Sci. 11, 5221-5226.

(114) Back CR, Higman VA, LeVay K, Patel VV, Parnell AE, Frankel D, Jenkinson HF, Burston SG, Crump MP, Nobbs AH and Race PR (2020)The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture.J Biol. Chem. 295, 6689-6699.

(113) Fage CD, Lathouwers T, Vanmeert M, Gao L-J, Vrancken K, Lammens E-M, Weir A, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné, J, Masschelein J. (2020) The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureusby targeting the enoyl-acyl carrier protein binding site of FabI. Angew. Chemie. Int. Ed. 59, 10549-10556.

(112) Walker PD, Rowe MT, Winter AJ, Weir AMN, After N, Wang L, Race PR, Williams C, Song Z, Simpson TJ, Willis CL, Crump MP (2020) Generation of 3-hydroxypropionate and 4-hydroxysuccinate starter units in the biosynthesis of mupirocin and thiomarinol. ACS Chem. Biol. 15, 494-503.

(111) Coffinet S, Meador TB, Mühlena L, Becker KW, Schröder J, Zhu Q-Z, Lipp JS, Heuer VB, Crump MP, Hinrichs K-U (2020) Structural elucidation and environmental distributions of butanetriol and pentanetriol dialkyl glycerol tetra ethers (BDGTs and PDGTs). Biogeosciences 17, 317-330.


(110) Hughes J, Surakhy M, Can S, Ducker M, Davies N, Szele F, Buhnemann Cm Carter E, Trikin R, Crump MP, Frago S, Hassan AB (2019) Maternal transmission of an Igf2r domain 11: IGF2 binding mutant (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression. Sci. Rep. 9, 11388.

(109) Goff KLP, Nicol D, Williams C, Crump MP, Zieleniewski F, Samphire JL, Baker EG, Woolfson DN (2019) Stabilizing aand understanding a miniprotein by rational design. Biochemistry, 58, 3060-3064.

(108) Walker PD, Williams C, Weir ANM, Wang L, Race PR, Crosby J, Simpson TJ, Willis CL, Crump MP (2019) Control of beta-branching in kalimantacin biosynthesis: Application of 13C NMR to polyketide programming. Angew. Chemie. Int. Ed. 58, 12446-12450.

(107) Landin EJB, Lovera S, Fabritiis, G de, Helm S, Mercier J, McMillan D, Sessions RB, Taylor RJ, Sands ZA, Joedicke L, Crump MP (2019) The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor. Angew. Chem. Int. Ed. 58, 9399-9403.

(106) Smith S, Sessions R, Shoemark D, Williams C, Crump MP, Smith M, Newby A and Bond M. (2019) Anti-proliferative effects of a novel YAP-TEAD protein-protein interaction inhibitor identified using in silico molecular docking. J. Med. Chem62, 1291–1305.

(105) Connolly JA, Wilson A, Macioszek M, Song Z, Wang L, Yadav M, di Martino M, Miller CE, Hothersall J, Haines A, Stephens ER, Crump MP, Willis CL, Simpson TJ, Winn PJ and Thomas CM (2019) Defining the final steps in biosynthesis of model polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586. Sci. Rep.9, 1542.

(104) Tromans RA,Carter TS, Chabanne L,Crump MP, Li H, Matlock JV, Orchard MG, Davis AP (2019) A biomimetic receptor for glucose. Nat. Chem. 11, 52-56.


(103) Winter AJ, Williams C, Isupov MN, Crocker H, Gromova M, Marsh P, Wilkinson OJ, Dillingham MS, Harmer NJ, Titball RW, Crump MP (2018) The molecular basis of HicA dependent binding of HicB to DNA. J. Biol. Chem. 293, 19429-19240.

(102) Wang L, Parnell A, Williams C, Nurfarhanim AB, Challand MR, van der Kamp, MW, Simpson TJ, Race PR, Crump MP, Willis CL (2018) A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis. Nature Catalysis 1, 968-976.

(101) Casanova E, Knowles TDJ, Williams C, Crump MP and Evershed RP (2018) Practical considerations in high-precision compound-specific radiocarbon analyses: eliminating the effects of solvent and sample cross-contamination on accuracy and precision. Anal. Chem. 90, 11025-11032.

(100) Lalaurie C, Dufour V, Meletiou A, Ratcliffe S, Harland A, Wilson O, Vamasiri C, Shoemark D, Williams C, Arthur C, Sessions R, Crump MP, Anderson J, Curnow P (2018) The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity membrane protein. Sci. Rep. 8, 14564.

(99) Crump MP, Goodwin M, Bakar NBA, Willis CL, Taylor R. Stable isotope protein labelling with micro-cryoprobe NMR for fragment screening. J. lab. Compd. Radiopharm. 61, 460.

(98) Ellis BD, Milligan JC, White AR, Duong V, Mohammed LY, Crump MP, Crosby J, Altman PX, Luo R, Vanderwal CD, Tsai S-C (2018) Oxetane-based polyketide surrogates to probe substrate specificity of polyketide synthases. J. Am. Chem. Soc. 1404961–4964.

(97) Jackson DR, Wattana-Amorn P, Vasilakis K, Mohammed L, Barajas J, Valentic T, Patel A, Aguilar S, Nguyen M, Vo M, Khanna A, Crump MP, Crosby J, Tsai S-C  (2018) ACS Chem. & Biol. 13, 141-151.


(96) Fisher GLM, Pastrana CL, Higman VA, Koh A, Taylor J, Butterer A, Craggs TD, Sobott F, Murray H, Crump MP, Moereno-Herrero F and Dillingham MS (2017) The C-terminal domain of ParB binds DNA and makes dynamic ParB-ParB bridging interactions to condense the bacterial centromere. eLIFE 6, e28086

(95) Watkins DW, Jenkins JM, Wood N, Grayson K, Kristian L-V, Armstrong CT, Crump MP, MacMillan F, Mulholland AJ, Sessions RB, Mann S, Anderson RJL (2017) Construction and in vivo assembly of a catalytically proficient, hyperthermostable de novo enzyme.  Nature Comm. 8, 358.

(94) Thistlethwaite IRG, Bull FM, Cui C, Gao S-S, Wang L, Walker PD, Song Z, Lavigne R, Crump MP, Race PR, Simpson TJ, Willis CL (2017) Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics. Chem. Sci. 8, 6196-6201.

(93) Casanova E, Knowles T, Williams C, Crump MP and Evershed RP (2017)  Use of a 700 MHz NMR microcryoprobe for the identification and quantification of exogenous carbon in compounds purified by preparative capillary gas chromatography for radiocarbon determinations. Anal. Chem. 89, 7090–7098.

(92) Baker EG, Hudson KL, Williams C, Bartlett GJ, Heal JW, Porter Goff KL, Sessions RB, Crump MP and Woolfson DN (2017) Engineering protein stability with atomic precision.  Nature Chem. Biol. 13,764–770. PMCID 5860740

(91) Ríos P, Mooibroek TJ, Carter TS, Williams C, Crump MP, Davis AP. (2017) Enantioselective carbohydrate recognition by chiral synthetic lectins in water. Chem. Sci. 8, 4056-4061.

(90) Gao S-S, Wang L, Song Z, Hothersall J, Stevens ER, Connolly J, Winn PJ, Cox RJ, Crump MP, Race P, Thomas CM, Willis CL, Simpson TJ. Selected mutations reveal new intermediates in the biosynthesis of mupirocin and thiomarinol antibiotics. (2017) Angew. Chemie. Int. Ed. 56, 3930-3934.


(89) Hexnerová R, Krízkova K, Fábry M, Sieglová I, Kedrová K, Collinsová M, Ullrichová P, Srb P, Williams C, Crump MP, Tosner Z, Jirácek J, Veverka V and Záková (2016) Probing receptor specificity by sampling the conformational space of the insulin-like growth factor II C-domain J. Biol. Chem. 291, 21234-21245. PMID: 27510031

(88) Carter TS, Mooibroek TJ, Stewart PFN, Crump MP, Galan MC, Davis AP (2016) Platform synthetic lectins for divalent carbohydrate recognition in water. Angew. Chem. Int. Ed. 55, 9311-9315.  PMID: 27312071

(87) Frago S, Nicholls RD, Strickland M, Hughes J, Williams C, Garner L, Surakhy M, Maclean R, Rezgui D, Prince SN, Zaccheo OJ, Ebner D, Sanegre S, Yu S, Buffa F, Crump MP* and Hassan AB* (2016) Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc. Natl. Acad. Sci. 113, 2766-2775.   PMID: 27140600 PMCID: PMC4878476

(86) Mooibroek TJ, Crump MP, Davis AP (2016) Submitted. Synthesis and evaluation of a desymmetrised synthetic lectin: an approach to carbohydrate receptors with improved versatility. Org. Biomol. Chem. 14,1930-1933. PMID: 26786502

(85) Rios P, Carter TS, Mooibroek TJ, Crump MP. Lisbjerg M, Pittelkow M, Supekar NT, Boons, G-J, Davis AP (2016) Synthetic receptors for the high-affinity recognition of O-GlcNAc derivatives. Angew. Chimie. Int. Ed. 55, 3387-3392. PMID: 26822115

(84) Dong X, Bailey CD, Williams C, Simpson TJ, Willis CL, Crump MP (2016) Recognition of extended and cyclised polyketide mimics by a Type II acyl carrier protein. Chem. Sci. 7, 1779-1785.

(83) Mooibroek TJ, Casas-Solvas JM, Harniman RL, Renney CM, Crump MP and Davis AP (2016) A threading receptor for polysaccharides. Nature Chem. 8, 69-74. PMID: 26673266 PMCID: PMC5856347


(82) Wattana-amorn P, Charoenwongsa W, Williams C, Crump MP and Apichaisataienchote (2015) Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. Strain 22-4 againts phytopathogenic bacteria. Nat Prod. Res. 30, 1980-1983.

(81) Senior L, Crump MP, Williams C, Mann S, Booth PJ, Perriman AW and Curnow P (2015) Structure and function of the silicifying peptide R5. J. Mat. Chem. B. 3, 2607-2614.

(80) Destecroix H, Renney CM, Mooibroek TJ, Carter TS, Stewart PFN, Crump MP, Davis AP (2015) Affinity Enhancement by dendritic side chains in synthetic carbohydrate receptors. Angew. Chemie Int. Ed. 54, 1-6.

(79) Baker EG, Bartlett GJ, Crump MP, Sessions RB, Linden N, Faul CFJ, Woolfson DN (2015) Local and macroscopic electrostatic interactions in charged free-standing a-helices. Nature Chem. Biol11, 221-8PMCID: PMC4668598

(78) Shoemark DK, Williams C, Fahey MS, Watson JJ, Tyler SJ, Scoltock SJ, Ellis RZ, Wickenden E, Burton AJ, Hemmings JL, Bailey CD, Dawbarn D, Jane DE, Willis CL, Sessions RB, Allen SJ and Crump MP* (2015) Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase A (TrkAIg2) Domain Construct for Binding Site Elucidation in Drug Discovery. J. Med. Chem. 58, 767-777. DOI:10.1021/jm501307e  PMCID: PMC4504729


(77) Gao S-S, Hothersall J, Wu J, Murphy AC, Song Z, Stephens ER, Thomas CM, Crump MP, Cox RJ, Simpson TJ and Willis CL (2014) Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 105 86 involves Parallel Pathways. J. Am. Chem. Soc. 136, 5501-5507

(76) Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014) The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J. 459, 333-444.

(75) Anderson JLR, Armstrong CT, Kodali G, Lichtenstein BR, Watkins DW, Mancini J, Boyle AL, Farid TA, Crump MP, Moser CC, Dutton PL. (2014) Constructing a man made, oxygen binding c-type cytochrome maquette in vivo. Chem. Sci. 5, 507-514.

(74) Murphy AC, Gao S-S, Han L-C, Carobene S, Fukuda D, Song Z, Hothersall J, Cox RJ, Crump MP, Thomas CM, Willis CL, Simpson TJ (2014) Biosynthesis of thiomarinaol A and related metabolites of pseudoalteromonas sp. SANK 73390. Chem Sci. 5, 397-402.


(73) Haines AS, Dong X, Song Z, Farmer R, Williams C, Hothersall J, Ploskon E, Wattana-Amorn P, Stephens ER, Yamada E, Gurney R, Takabayashi Y, Masschelein J, Lavigne R, Crosby J, Simpson TJ, Winn PJ, Thomas CM, Crump MP. (2013) Nat. Chem. Biol. 9, 685-692PMID:24056399 PMCID:PMC4658705   

(72) Pouya J, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai S-C (2013) The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase (ActKR) Chem. Biol. 20, 1089-1091.

(71) Maple HJ, Garlish, R, Whitcombe I, Hold, A, Prosser, C, Ford, D, Mackenzie, H, Crosby J, Porter, J, Taylor R, Crump, MP (2013) Identification of differential protein binding affinities in an atropisomeric pharmaceutical compound using non-covalent mass spectrometry, equilibrium dialysis and NMR. Anal. Chem. 85, 5958-5964.

(70) Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB.-M, Crump MP, Allemann RK (2013) 1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide. Biomol. NMR Assign. 7, 187-191.

(69) Aliphatic 1H, 13C, 15N chemical shift assignments of dihydrofolate reductase from psychropiezophile Moritella profunda in complex with NADP+ and folate. Biomol. NMR Assign. 7, 61-64.

(68) Howgego JD, Butts CP,Crump MP, Davis AP (2013) An accessible bicyclic architecture for synthetic lectins. Chem. Comm. 49, 3110-3112.

(67) Fuengfuloy, P., Suwimon S, Wattana-Amorn P, Williams C, Crump MP, Chomphunuch S (2013) Overproduction of the N-terminal Anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Heliobacter pylori for crystallisation and NMR measurements. Prot. Exp. and Purif. 89, 25-32.



(66) Williams C, Hoppe H, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, MungallAJ, Jones EY, Crump MP, Hassan AB (2012) An Exon Splice Enhancer primes IGF2-IGF2R binding site structure and function evolution. Science 238, 1209-1213.

PMID:23197533 PMCID:PMC4658703

(65) Crosby J, Treadwell T, Hammerton M, Vasilakis K, Crump MP, Williams DS, Mann S (2012) Stabilisation and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer/nucleotide coacervate droplets. Chem. Comm. 48, 11832-11834.

(64) Crosby J and Crump MP (2012) The structural role of the carrier protein – active controller or passive carrier. Nat. Prod. Rep. 29, 1111-1137

(63) Ke C, Destecroix H, Crump MP, Davis AP (2012) A simple and accessible lectin for glucose recognition and sensing. Nat. Chem. 4, 718-723.

(62) Wysoczanski P, Mart RJ, Loveridge JE, Williams C, Whittaker SBM, Crump MP, Allemann RK (2012) Solution structure of a photo-switchable apoptosis activating Bak peptide bound to Bcl-xL J. Am. Chem. Soc. 134, 7644-7647.

(61) Loveridge EL, Williams C, Whittaker SBM, Günther UL, Crump MP, Allemann RK (2012) Aliphatic 1H, 13C and 15N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda incomplex with NADP+ and folate. Biomol. NMR Assign. (Online) DOI 10.1007/s121040129378-x.

(60) Sookcharoenpinyo B, Klein E, Ferrand E, Walker DB, Brotherhood PR, Ke C, Crump MP, Davis AP (2012) High-affinity disaccharide binding by tricyclic synthetic lectins. Angewandte Chem. Int. Ed. 51, 4586-4590

(59) Maple HJ, Garlish RA, Rigau-Roca L, Porter J, Whitcombe I, Prosser CE, Kennedy J, Henry AJ, Taylor RJ, Crump MP, Crosby J. (2012) High-throughput fragment screening by mass spectrometry J. Med. Chem. 55, 837-851.



(58) Loveridge EJ, Tey L-H, Behiry EM, Dawson WM, Evans RM, Whittaker SBM, Gunther UL, Williams C, Crump MP, Allemann RK (2011) The role of large scale motions in catalysis by dihydrofolate reductase. J. Am. Chem. Soc. 133, 20561-20570.

(57) Allen SJ, Shoemark DK, Hemmings JL, Bailey CD, Fahey MS, Tyler SJ, Williams C, Scoltock SJ, Watson JJ, Willis CL, Crump MP, Sessions RB, Jane DE (2011) Therapeutic agent and drug design targets: Brain NGF Receptors. J. Physhopharm. 25, A11.

(56) Dall’aglio P, Arthur CJ, Crosby J, Crump MP, Hadfield A (2011) Analysis of Streptomyces coelicolor phosphopantetheinyl transferase, AcpS reveals basis for substrate and cofactor promiscuity. Biochemistry 50, 5704-5717.

(55) Brown C, Campos K, Williams C, Fairweather V, Brady RL, Crump MP Gaston K (2011) Protein felixibility directs DNA recognition by the papillomavirus E2 proteins. Nucl. Acid Res. 39, 2969-2980.



(54) Ploskon E, Arthur CJ, Kanari A, Williams C, Wattana-Amorn P, Crosby J, Willis C, Crump MP (2010) Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis Chem. & Biol. 17, 776-785.

(53) Wattana-Amorn P, Williams C, Cox RJ, Crosby J, Simpson TJ, Crump MP (2010) Solution structure of an acyl carrier protein domain from fungal Type I polyketide synthase. Biochemistry. 49, 2186-2193.

(52) Bromley EHC, Channon KJ, King PJS, Mahmoud ZN, Banwell EF, Butler MF Crump MP , Dafforn TR, Hicks MR, Hirst JD, Rodger A, Wolfson DN (2010) The assembly pathway of a designed a-helical protein fiber. Biophys. J. 98, 1668-1676



(51) James MA, Mukherjee AJ, Crump MP, Gates PJ, Hoffman E, Robertson F, Pfälzner P, Evershed RP (2009) Identification of Royal purple in anthropogenic sediments from a Bronze Age Syrian Royal Tomb. Antiquity. 83, 1109-1118.

(50) Barwell NP, Crump MP, Davis AP (2009) A synthetic lectin for -Glucosyl. Angew. Chemie. Int. Ed. 48, 7673-7676.

(49) Arthur CJ, Williams C, Pottage K, Ploskon E, Findlow ISC, Burston SG, Simpson TJ, Crump MP, Crosby J (2009) Structure and malonyl CoA-ACP transacylase binding of Streptomyces coelicolor fatty acid synthase acyl carrier protein ACS Chem. Biol. 4, 623-636.

(48) Gill FL, Crump MP, Bull ID (2009) Lipid analysis of a ground sloth coprolite Quat. Rev. 72, 284-288

(47) Evans SE, Williams C, Arthur CJ, Ploskon E, Crosby J, Cox RJ, Willis CL, Simpson TJ, Crump MP. (2009) Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3(2). J. Mol. Biol. 389, 511-528.

(46) Beltran-Alvarez P, Arthur CJ, Cox RJ, Crosby J, Crump MP, Simpson TJ (2009) Preliminary Kinetic Analysis of Acyl Carrier Protein:Ketoacylsynthase Interactions in the Actinorhodin Minimal Polyketide Synthase. Mol. Biosyst. 5, 511-518.

(45) Rezgui D, Williams C, Zaccheo OJ, Savage S, Prince SN, Jones Y, Crump MP, Hassan AB (2009) Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth. Mol. Endocrinol. 42, 341-356.

(44) Ferrand Y, Klein E, Barwell NP, Crump MP, Jiménez-Barbero J, Vincent C, Ingale S, Boons G-J, Davis AP (2009) A synthetic lectin for O-linked b-N-Acetylglucosamine (O-GlcNAc). Angew. Chemie Int. Ed. 48, 1175-1779.



(43) Kneissel S, Loveridge EJ, Williams C, Crump MP, Alleman RK (2008) Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL. ChemBioChem. 9, 3046-3054.

(42) Castaldo G, Zucko J, Heidelberger S, Vujaklija D, Hranueli D, Wattana-Amorn P, Crump MP, Crosby J and Long PF (2008) Proposed arrangement of proteins forming a bacterial type II polyketide synthase. Chem. & Biol. 15, 1156-1165.

(41) Evans S, Arthur CA, Simpson TJ, Crosby J, Williams C, Crump MP (2008) A structural switch identified between apo and holo forms of actinorhodin polyketide synthase ACP. ChemBioChem. 9, 2424-2432.

(40) Scheschonka, A Findlow S, Schemm R, El Far O, Caldwell JH, Crump MP, Holden-Dye K, O’Connor V, Betz H & Werner JM (2008) Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A. J. Biol. Chem. 283, 5577-5588.

(39) Halo LM, Marshall JW, Yakasai AA, Zhongshu S, Butts CP, Crump MP, Heneghan M, Bailey AM, Simpson TJ, Lazarus CM, Cox RJ (2008) Authentic Heterologous Expression Of The Tenellin Iterative Polyketide Synthase Non-Ribosomal Peptide Synthetase requires co-expression with an enoyl reductase ChemBioChem 9, 585-594.

(38) Ploskon, E, Williams C, Evans S, Crosby J, Simpson TJ, Crump MP. (2008) High resolution NMR studies reveal the type I rat FAS ACP is unique in not binding fatty acids. J. Biol. Chem. 283, 518-528.



(37) Ferrand Y, Crump MP, Davis AP. A Synthetic Lectin for Biomimetic Dissacharide recognition. (2007) Science 318, 619-622.

(36) Williams C, Rezgui D, Prince SN, Zaccheo OJ, Foulstone EJ, Forbes BE, Norton RS, Crosby J, Hassan AB, Crump MP. (2007) Structural insights into the interaction of insulin growth factor II (IGF-II) with IGF2R domain 11. Structure 15, 1065-1078.

(35) Slupsky C, Spyracopoulos L, Booth V, Sykes BD, Crump MP (2007) Probing nascent structures in peptides using reduced spectral density mapping and natural abundance 13C NMR relaxation. Proteins. Struct. Func. Genet. 67:18-30.

(34) Wu J, Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Simpson TJ, Thomas CM, Willis, CL. (2007) Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens. Chem. Comm. 20: 2040-2042.



(33) Simpson GL, Gordon AH, Lindsay DM, Promaswan N, Crump MP, Mulholland K, Hayter BR, Gallagher T. (2006) Glycosylated foldamers as probes to elicit the molecular detail of carbohydrate-carbohydrate interactions. J. Am. Chem. Soc. 128, 10638-10639.

(32) Arthur CJ, Szafranska AE, Long J, Mills J, Cox RJ, Findlow S, Simpson TJ, Crump MP, Crosby, J. (2006) The malonyl transferase activity of Type II polyketide synthase acyl carrier proteins Chem. Biol. 13, 587-596.

(31) Zaccheo OJ, Prince SN, Miller DM, Williams C, Brown J, Yvonne Jones E, Crump MP, Hassan AB. (2006) Kinetics of Insulin-like growth factor II (IGF-II) interaction with domain 11 residues of the IGF-II/Mannose 6-phosphate receptor; Identification of binding site positive and negative regulators. J. Mol. Biol. 359, 403-421.



(30) Arthur CJ, Szafranska A, Evans S, Findlow SC, Burston SG, Owen P, Clark-Lewis I, Simpson TJ, Crosby J, Crump MP. (2005) Self-malonylation is an intrinsic property of a chemically synthesized Type II polyketide synthase acyl carrier protein. Biochemistry 44, 15414-15421.

(29) Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Laosripaiboon W, Simpson TJ, Thomas CM (2005) Mupirocin W, a Novel Pseudomonic Acid Produced by Targeted Mutation of the Mupirocin Biosynthetic Gene Cluster. Chem. Comm. 9, 1179-1181.

(28) Klein E, Crump MP, Davis, AP (2005) Carbohydrate recognition in water by a tricyclic polyamide receptor. Angew. Chemie Int. Ed. 44, 298-302.



(27) Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP (2004) The Crystal Structure of the Actinorhodin Polyketide Reductase (actIII): Proposed mechanism for ACP and Polyketide Binding. Structure 12:1865-1875.

(26) Parker CA, Anderson NJ, Robinson ESJ, Price R, Tyacke RJ, Husbands SM, Dillon MP, Eglen RM, Hudson AL, Nutt DJ, Crump MP, Crosby J (2004) Harmane and Harmalan are the Bioactive Components of “Classical” Clonidine Displacing Substance. Biochemistry 43:16385-16392.

(25) Teartasin W, Limpkin C, Glod F, Spencer J, Cox RJ, Crosby J, Crump MP, Hadfield A (2004) Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a Type II polyketide synthase. Acta Cryst. D60, 1137-1138.

(24) Crump MP, Ceska TA, Spyracopoulos L, Henry A, Archibald SC, Alexander R, Taylor RJ, Findlow SC, O’Connell J, Robinson MK, Shock A (2004) The structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR and calorimetry. Biochemistry 43, 2394-2404.



(23) Findlow IS, Winsor C, Simpson TJ, Crosby J, Crump MP (2003) Solution structure and dynamics of Oxytetracycline polyketide synthase ACP from S. rimosus. Biochemistry 42, 8423-8433.

(22) Housden, HR, Skipp, PJS, Crump, MP, Broadbridge, RJ, Crabbe, T, Perry, MJ, Gore, MG (2003) Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor  chain by the protein tyrosine kinase Lck. (2003) Eur. J. Biochem. 270, 2369-2376.

(21) Reed MAC, Schweizer M, Szafranska AE, Arthur C, Nicholson TP, Cox RJ, Crosby J, Crump MP and Simpson TJ (2003) The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type I ACPs Org. Biomol. Chem. 1, 463-471.



(20) Graille M, Harrison S, Crump MP, Findlow SC, Housden NG, Muller BH, Battail-Poirot N, Sibai G, Sutton BJ, Taussig MJ, Jolivet-Reynaud C, Gore MG, Stura EA. (2002) Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface. J. Biol. Chem. 277, 47500-47506.

(19) Shoolingin-Jordan PM., Crump MP. (2002) Phosphopantetheine dependent enzymes. Encyclopedia of Life Sciences. (electronic publication).

(18) Crump MP, Shoolingin-Jordan, PM (2001) CoA dependent enzymes. Encyclopedia of Life Sciences. (electronic publication).

(17) Coates L, Erskine PT, Crump MP, Wood SP, Cooper JB. (2002) Five atomic resolution structures of endothiapepsin inhibitor complexes; implications for the aspartic proteinase mechanism. J. Mol. Biol. 318, 1405-1415.



(16) Spyracopoulos L, Lavigne P, Crump MP, Gagné SM, Kay CM, Sykes BD (2001) Temperature dependence of dynamics and thermodynamics of the regulatory domain of human cardiac troponin C. Biochemistry 40, 12541-12551.

(15) Keizer DW, Slupsky CM, Kalisiak, M, Campbell AM, Crump MP, Sastry PA, Hazes B, Irvin RT, Sykes, BD. (2001) Structure of a Pilin Monomer from Pseudomonas aeruginosa: Implications for the assembly of Pili. J. Biol. Chem. 276, 24186-24193.

(14) Keizer DW., Kalisiak, M., Crump, MP., Suh, J-H., Irvin RT., Sykes, BD. (2001) Assignments of 1H and 15N resonances of the Pseudomonas aeruginosa K122-4 pilin monomer J. Biomol. NMR. 19, 385-386.

(13) Crump MP, Elisseeva E, Gong, J-H, Sykes BD, Clark-Lewis I. (2001) Structure/Function of Human Herpesvirus-8 MIP-II (1-71) and the N-terminal segment (1-10). FEBS Lett. 489, 171-175.



(12) Slupsky CL, Elisseeva EL, Crump MP, Clark-Lewis I, Sykes BD. (2000) NMR studies of active N-terminal peptides of Stromal Cell-derived factor-1: Structural basis for receptor binding. J. Biol. Chem. 275, 26834-26841.

(11) Keizer, DW, Crump MP, Slupsky CM., Lee, T-W., Clark-Lewis, I, Sykes, BD (2000) Solution structure of the human CC chemokine, I-309: A chemokine with three disulfide bonds. Biochemistry 39, 6053-6059.

(10) Spyracopoulos L, Lavigne R, Crump MP, Gagne S, Sykes BD (2000) Temperature dependence of dynamics and thermodynamics of the regulatory domain of human cardiac troponin C in the APO state. Biophys. J. 78: (1) 434A Part 2.



(9) Crump MP, Spyracopolous L, Lavigne P, Kim K-S, Clark-Lewis I, Sykes BD. (1999) Backbone dynamics of the human chemokine eotaxin: Fast motions, slow motions and possible implications for receptor binding. Protein Science 8, 2041-2054.

(8) Rajarathnam K., Crump MP, Clark-Lewis I, Sykes BD (1999) Spectroscopic Characterization of Chemokines: Relevance for Quality Control and Standardization In Biological Characterization and Assay of Cytokines and Growth Factors. Dev. Biol. Stand., Brown, F., Mire-Sluis, A.R. (eds) Karger, Basel, Switzerland, Volume 97, 49-57.



(7) Crump MP, Rajarathnam K, Kim K-S, Clark-Lewis I, Sykes BD. (1998) Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. J. Biol. Chem. 273, 22471-22479.

(6) Crosby J, Byrom KJ, , Hitchman TS, Cox RJ, Crump MP, Findlow SC, Bibb MJ, Simpson TJ. (1998) Acylation of Streptomyces Type II polyketide synthase acyl carrier proteins. FEBS Lett. 433:132-138.

(5) Lavigne P, Crump MP, Gagné SM, Hodges RS, Kay CM, Sykes BD. (1998) Insights into the mechanism of heterodimerisation from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. J. Mol. Biol. 281:165-181.



(4) Crump MP, Gong J-H, Loetscher P, Rajarathnam K, Amara A, Arenzana-Seisdedos F, Virelizier J-L, Baggiolini M, Sykes BD, Clark-Lewis I. (1997) Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J. 16:6996-7007.

(3) Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ. (1997) Solution structure of the Actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). Biochemistry 36:6000-6008.

(2) Lavigne P, Crump MP, Gagné S, Sykes BD, Kay C. (1997) 1H NMR evidence for two buried Asn side-chains in the c-Myc-Max Heterodimeric alpha-helical coiled coil. Techniques in Protein Chemistry Vol VIII, 617-623.


(1) Crump MP, Crosby, J, Dempsey CE, Murray M, Hopwood DA, Simpson TJ. (1996) The Polyketide Acyl Carrier Protein from Streptomyces coelicolor A3(2) and the E. coli Fatty Acid ACP show conserved Secondary Structure. FEBS Lett. 391, 302-306.