Recent Paper: The Aminotriazole Antagonist Cmpd‐1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor

A very well done to everyone involved in this recent paper published in Angewandte Chemie. In this paper, 19F NMR has been used to study activation and inactivation of the A2A adenosine receptor. A compound with potential as an anti Parkinson’s drug was found to stabilise a novel inactive state of the A2A adensone receptor that is distinct from the standard inactive state observed in the literature.

The key finding of the paper is summarised in the below image.

A) Normalised 19F NMR spectra of V2296.31C. A similar 19F chemical shift is observed when A2AR is exposed to three different antagonists, distinct from the agonist NECA B) 19F NMR spectra of K2095.70C. Cmpd‐1 causes the receptor to report a distinct state.

Paper can be found using the following link: