Recent Paper: A Priming Cassette Generates Hydroxylated Acyl Starter units in Mupirocin and Thiomarinol Biosynthesis.

The Crump group is pleased to announce the publication of recent work in ACS Chemical Biology Journal. This work was completed as a collaboration between the Departments of Chemistry and Biochemistry at the University of Bristol, showing the need for frequent collaboration in the field of biosynthesis of natural products.

This work utilises a plethora of laboratory techniques to fully characterise the formation of a 3-carbon alcohol intermediate in the biosynthesis of the polyketide antibiotic mupirocin and homologous 4-carbon alcohol intermediate in the biosynthesis of thiomarinol.

This is exciting work and provides a solid contribution to the biosynthetic community, well done to all involed in the publication of this work.

A link to the paper can be found at the following link:


Recent Paper: The Aminotriazole Antagonist Cmpd‐1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor

A very well done to everyone involved in this recent paper published in Angewandte Chemie. In this paper, 19F NMR has been used to study activation and inactivation of the A2A adenosine receptor. A compound with potential as an anti Parkinson’s drug was found to stabilise a novel inactive state of the A2A adensone receptor that is distinct from the standard inactive state observed in the literature.

The key finding of the paper is summarised in the below image.

A) Normalised 19F NMR spectra of V2296.31C. A similar 19F chemical shift is observed when A2AR is exposed to three different antagonists, distinct from the agonist NECA B) 19F NMR spectra of K2095.70C. Cmpd‐1 causes the receptor to report a distinct state.

Paper can be found using the following link: